LJ 001

Research use only, not for human use.

LJ 001 ((LJ-001, LJ001)?is a broad-spectrum antiviral agent targeting entry of enveloped viruses.

LJ 001 ((LJ-001, LJ001)?is a broad-spectrum antiviral agent targeting entry of enveloped viruses, including influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1; specifically intercalates into viral membranes, irreversibly inactivates virions while leaving functionally intact envelope proteins, and inhibits viral entry at a step after virus binding but before virus-cell fusion; specifically inhibits virus-cell but not cell-cell fusion.

Cell Viability Assay Cell Line:ST cells Concentration:0.782, 1.563, 3.125, 6.25, 12.5, 25, 50, 100, 200 μM Incubation Time:24 h Result:Showed slight cytotoxicity with a CC50 value of 146.4 μM.Western Blot Analysis Cell Line:ST cells Concentration:12.5 μM Incubation Time:12, 24 h Result:Decreased the expression of TGEV N protein and PDCoV N-protein at 24 h and markedly reduced TCID50 titers at 12 and 24 h.RT-PCR Cell Line:ST cells Concentration:12.5 μM Incubation Time:1, 6, 12, 24 h Result:Inhibited TGEV and PDCoV gene mRNA expression in a time-dependent manner.

Animal Model:Female BALB/c mice Dosage:20, 50 mg/kg Administration:Oral gavage or i.p.; daily for 7 days Result:Revealed no abnormalities except a slight elevation in serum cholesterol levels in the treated vs. vehicle control group.

LJ001 | LJ-001

Microbiology/Virology

Influenza Virus

Influenza Virus

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851305-26-5

327.42

C17H13NO2S2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (305.42 mM)

O=C1N(CC=C)C(S/C1=C\C2=CC=C(C3=CC=CC=C3)O2)=S

(5Z)-5-[(5-phenylfuran-2-yl)methylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one

(-20℃)

With Ice Pack

≥ 2 years